Question: How Myeloma Treatment Adversely Affects Elderly Patients?

Patients with multiple myeloma aged older than 65 years have traditionally received an oral regimen combining melphalan and prednisone (MP). The introduction of novel agents, such as immunomodulatory drugs and proteasome inhibitors, has substantially changed the treatment paradigm of this disease.

What is the major complication that a patient must be concerned if diagnosed with multiple myeloma?

In people with multiple myeloma, the growing number of cancerous cells can interfere with the production of all types of blood cells. Decreased production of red blood cells can result in a complication called anemia.

What are the symptoms of dying from myeloma?

But when you have late-stage multiple myeloma, your symptoms may show up as:

  • Being sick to your stomach.
  • Bone pain in your back or ribs.
  • Bruising or bleeding easily.
  • Feeling very tired.
  • Fevers.
  • Frequent infections that are hard to treat.
  • Losing a lot of weight.
  • Not feeling like eating.

Is myeloma common in elderly?

Multiple myeloma (MM) is a common disease among the elderly with a median age of 70 years at diagnosis and many patients diagnosed at ≥75 (~30%) and ≥85 years (~10%) [1, 2].

How do people cope with multiple myeloma?

Here are some tips for coping with multiple myeloma:

  1. Understand your diagnosis.
  2. Communicate openly with your treatment team.
  3. Find help to manage your symptoms.
  4. Report any side effects.
  5. Learn to relax your mind and body.
  6. Seek extra support.

What is the last stage of multiple myeloma?

In multiple myeloma cases, stage 3 is the terminal stage. This means it’s the most advanced stage of this type of rare cancer. Doctors use the international staging system to determine the stage of the cancer. This system is based on the levels of serum beta-2 microglobulin and serum albumin.

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What is the most aggressive form of multiple myeloma?

IgE multiple myeloma causes the same signs and symptoms as other types of multiple myeloma. It tends to be aggressive and progresses to plasma cell leukemia or spreads outside the bone marrow quickly.

How do you know when multiple myeloma is getting worse?

As active multiple myeloma gets worse, you’ll likely feel sicker, with fatigue or bone pain. You may have anemia, bleeding problems, or a lot of infections. Other symptoms of advanced multiple myeloma include unusual fractures, shortness of breath, weakness, feeling very thirsty, and belly pain.

What are the first signs of your body shutting down?

Signs that the body is actively shutting down are:

  • abnormal breathing and longer space between breaths (Cheyne-Stokes breathing)
  • noisy breathing.
  • glassy eyes.
  • cold extremities.
  • purple, gray, pale, or blotchy skin on knees, feet, and hands.
  • weak pulse.
  • changes in consciousness, sudden outbursts, unresponsiveness.

Is myeloma a painful death?

Experiencing a Peaceful Passing Accounts of those who have accompanied a loved one as they died from complications of multiple myeloma generally report a relatively calm death in which pain has been effectively managed.

How is multiple myeloma treated in the elderly?

Therapy at diagnosis MPT and melphalan-prednisone-bortezomib are the reference treatments for elderly patients ineligible for high-dose therapy. Recently, continuous lenalidomide-dexamethasone (Rd) was shown to be more effective than MPT at diagnosis.

How Long Can multiple myeloma patients live without treatment?

“I have seen patients live from several weeks to more than 20 years after being diagnosed,” Dr. Hillengass says. Multiple myeloma is a cancer of cells of the immune system which can cause symptoms like holes in the bones (osteolytic lesions), kidney failure, low blood counts and high calcium in the blood.

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Is myeloma a terminal?

Treatment for myeloma can be very effective at controlling the disease, relieving its symptoms and complications, and prolonging life. Unfortunately, though, myeloma is currently an incurable (terminal) cancer. Myeloma is a relapsing-remitting cancer.

How successful is myeloma treatment?

Treatments for myeloma can be very effective at controlling the disease, reducing symptoms and improving quality of life. Unfortunately, however, myeloma is currently an incurable (terminal) cancer. In general, treatment is given to: Reduce the levels of myeloma as far as possible.

What is considered a high level of M protein?

High levels mean the disease is more advanced and may indicate a poor prognosis. The presence of any M spike is abnormal and shows the presence of an abnormal clone of plasma cells. If the amount of protein is ≥30 g/L and/or there are other disease symptoms, the patient may have myeloma.

Does multiple myeloma always return?

If you have multiple myeloma, there’s a good chance it will come back after successful treatment. When this happens, it’s called recurrent or relapsed. If it doesn’t respond to treatment or comes back within 60 days after your last therapy, it’s known as refractory.

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