SSRIs considered to have the best safety profile in the elderly are citalopram, escitalopram, and sertraline.  These have the lowest potential for drug-drug interactions based on their cytochrome P-450 interactions.
Which antidepressant should be avoided in the elderly?
Tricyclic antidepressants, especially amitriptyline and dothiepin,16 are known to pose a high risk of death in overdosage. These drugs should therefore be avoided in older people whose medication is not supervised and who are at risk of taking an overdose.
What is the best anti anxiety medication for elderly?
Buspirone is an anti-anxiety drug that has been shown to be effective for older adults. Benzodiazepines, another anti-anxiety drug, are effective but should be prescribed carefully to older adults because of risk of memory impairment, unsteadiness, and falls.
What is the mildest and safest antidepressant?
Bupropion, citalopram, escitalopram, and sertraline were better tolerated than the other antidepressants. Escitalopram and sertraline were found to have the best combination of efficacy and acceptability.
Is Zoloft safe for seniors?
Sertraline is generally well tolerated in elderly patients with major depressive disorder and lacks the marked anticholinergic effects that characterise the adverse event profiles of tricyclic antidepressants (TCAs).
What is the safest antidepressant?
Among the newer antidepressants, bupropion and venlafaxine were associated with the highest case fatality rates. In addition, among SSRIs, citalopram and fluvoxamine appeared to be related to higher mortality rates in overdose, whereas fluoxetine and sertraline were the safest .
Is Paxil safe for elderly?
However, elderly patients may be more sensitive to the effects of this medicine than younger adults, and are more likely to have hyponatremia (low sodium in the blood), which may require caution and an adjustment in the dose for patients receiving paroxetine.
Is Wellbutrin safe for the elderly?
PARIS, FRANCE — September 20, 2006 — Once-daily use of an extended-release formulation of bupropion (Wellbutrin XL(R)) is both efficacious and safe in elderly patients with major depressive disorder, according to a multicentre, randomised, double-blind, flexible-dose, placebo-controlled trial.
Is Lexapro good for elderly?
They said antidepressants like Lexapro, made by Forest Laboratories Inc and known generically as escitalopram, may be useful as a new treatment option for older adults with generalized anxiety disorder, a disabling condition that can also cause muscle tension, insomnia and fatigue.
Which antidepressants have the least amount of side effects?
Selective serotonin reuptake inhibitors (SSRIs). These medications generally cause fewer bothersome side effects and are less likely to cause problems at higher therapeutic doses than other types of antidepressants are.
What is the number one antidepressant?
Zoloft is the most commonly prescribed antidepressant; nearly 17% of those surveyed in the 2017 antidepressant use study reported that they had taken this medication. 3. Paxil (paroxetine): You might be more likely to have sexual side effects if you choose Paxil over other antidepressants.
What is better Prozac or Zoloft?
In a double-blind, clinical trial, both Zoloft and Prozac improved depression based on different scores for depression and anxiety as well as sleep. While both SSRIs were found to be effective, Zoloft was found to have lower severity of side effects.
What is the best antidepressant for anxiety and panic?
SSRIs approved by the Food and Drug Administration (FDA) for the treatment of panic disorder include fluoxetine (Prozac), paroxetine (Paxil, Pexeva) and sertraline (Zoloft). Serotonin and norepinephrine reuptake inhibitors (SNRIs). These medications are another class of antidepressants.
Is Zoloft linked to dementia?
According to the University of Regina research, popular SSRI (Selective Serotonin Reuptake Inhibitors) antidepressant medications, such as Prozac, Paxil, Lexapro, Zoloft, etc., are associated with a twofold increase in the odds of developing some form of cognitive impairment, such as dementia, including Alzheimer’s.
Which mood stabilizers are preferred for use in the geriatric population?
Lithium remains the treatment of choice for bipolar mania in elderly patients. Although lithium has greater proven efficacy than other mood stabilizers with respect to treating and preventing manic episodes and reducing suicidal behavior17 there is a dearth of good studies of its use in the elderly population.
What drug should be avoided in geriatric patients?
AVOID Certain Anticholinergic Drugs
- Antidepressants amitriptyline (Elavil) and imipramine (Tofranil)
- Anti-Parkinson drug trihexyphenidyl (Artane)
- Irritable bowel syndrome drug dicyclomine (Bentyl)